Across TCGA cell cohorts, MT-ND3 mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MT-ND3-associated genes across cancer lineages are MS4A6E, OR5M11, and DEFB126. Each is linked with MT-ND3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MT-ND3-to-partner and partner-to-MT-ND3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT-ND3→partner) and Y-score (partner→MT-ND3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MS4A6E →	+0.102	+2.966	<.001	.001	3	2
LARGE_INTESTINE	OR5M11 →	+0.140	+4.095	<.001	.003	3	2
OVARY	DEFB126 →	+0.109	+4.260	<.001	<.001	3	2
CNS	KLRB1 →	+0.054	+4.054	<.001	.004	3	2
LUNG_SCLC	PVALB →	+1.270	+3.428	.001	.008	2	2
LIVER	GPR33 →	+0.011	+2.874	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

Exploration

MT-ND3 survival (RNA) · tumor vs normal (RNA) · all MT-ND3 data types