Across TCGA cell cohorts, MT-ND2 mutation is significantly associated with the RNA expression of many other genes, with 1,550 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MT-ND2-associated genes across cancer lineages are IER2, TRIM14, and SPDYE6. Each is linked with MT-ND2 in more than 4 cancer types. Because this analysis shows association rather than direction, both MT-ND2-to-partner and partner-to-MT-ND2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT-ND2→partner) and Y-score (partner→MT-ND2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IER2 →	+0.686	+2.265	.001	.001	3	5
BLOOD_Leukemia	TRIM14 →	+1.220	+4.029	<.001	<.001	3	4
CNS	SPDYE6 →	+0.679	+3.700	<.001	<.001	3	4
BLOOD_Leukemia	UGGT1 →	+0.503	+2.252	.006	.003	3	4
CNS	SPDYE2B →	+0.276	+3.469	.002	.003	2	5
URINARY_TRACT	ELOA3P →	+0.059	+3.769	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,550 associations by consensus.

Exploration

MT-ND2 survival (RNA) · tumor vs normal (RNA) · all MT-ND2 data types