Across TCGA patient cohorts, MT-ND1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,558 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MT-ND1-associated genes across cancer lineages are TCF23, ALDH5A1, and SIRT5. Each is linked with MT-ND1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MT-ND1-to-partner and partner-to-MT-ND1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT-ND1→partner) and Y-score (partner→MT-ND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TCF23 →	-1.041	-0.658	<.001	.007	3	3
GBM	ALDH5A1 →	+0.610	+0.453	<.001	<.001	3	3
LSCC	SIRT5 →	+0.674	+0.364	<.001	<.001	3	3
GBM	TREM1 →	-1.402	-0.658	<.001	<.001	3	3
LSCC	GID4 →	+0.495	+0.291	<.001	.001	3	3
BRCA	EFEMP1 →	-0.870	-0.375	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,558 associations by consensus.

Exploration

MT-ND1 survival (RNA) · tumor vs normal (RNA) · all MT-ND1 data types