Across TCGA pan-cancer cohorts, MT-ND1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MT-ND1 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher MT-ND1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MT-ND1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

SKCM, BRCA, and PAAD are the cancer types where MT-ND1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.264	0.401	<.001	53	view →
BRCA	DFS	Median	II,III,IV	0.921	0.855	<.001	53	view →
PAAD	DFS	Tertile	All	0.595	0.283	<.001	43	view →
THYM	DFS	Tertile	All	0.762	0.955	.002	37	view →
ACC	DFS	Median	III,IV	0.093	0.555	<.001	33	view →
COAD	DFS	Tertile	IV	0.189	0.673	.003	24	view →
SARC	OS	Median	All	0.748	0.437	<.001	23	view →
KICH	DFS	Quartile	All	0.901	0.462	.006	21	view →
KIRP	DFS	Tertile	IV	0.528	0.035	.010	16	view →
LUSC	DFS	Tertile	II,III,IV	0.913	0.559	.006	13	view →
LGG	OS	Quartile	All	0.741	0.401	.001	12	view →
PRAD	DFS	Median	All	0.850	0.917	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

Exploration

Same gene, other analysis: MT-ND1 tumor-vs-normal RNA expression · all MT-ND1 data types