Across TCGA cell cohorts, MT-CO2 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MT-CO2-associated genes across cancer lineages are MAGEB4, LRRC72, and GH2. Each is linked with MT-CO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MT-CO2-to-partner and partner-to-MT-CO2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT-CO2→partner) and Y-score (partner→MT-CO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MAGEB4 →	+0.006	+5.662	<.001	.002	3	2
LUNG_SCLC	LRRC72 →	+0.027	+2.847	<.001	.009	3	2
URINARY_TRACT	GH2 →	+0.022	+4.087	<.001	.009	3	1
URINARY_TRACT	OR6N1 →	+0.010	+4.087	<.001	.009	3	1
URINARY_TRACT	TMEM88B →	+0.899	+4.217	<.001	.005	3	1
KIDNEY	MYL10 →	+0.077	+3.947	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

MT-CO2 survival (RNA) · tumor vs normal (RNA) · all MT-CO2 data types