Across TCGA pan-cancer cohorts, MT-CO1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MT-CO1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MT-CO1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MT-CO1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and OV show a favorable association.

CCRCC, OV, and HNSC are the cancer types where MT-CO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.844	0.615	.002	23	view →
OV	DFS	Tertile	All	0.942	0.688	.045	8	view →
HNSC	DFS	Tertile	III,IV	0.772	0.502	.018	5	view →
UCEC	DFS	Median	All	0.935	1.000	.019	4	view →
LUAD	DFS	Median	III,IV	0.709	0.285	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: MT-CO1 tumor-vs-normal RNA expression · all MT-CO1 data types