Across TCGA cell cohorts, MT-ATP8 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MT-ATP8-associated genes across cancer lineages are GZMH, GZMK, and LCN1. Each is linked with MT-ATP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MT-ATP8-to-partner and partner-to-MT-ATP8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT-ATP8→partner) and Y-score (partner→MT-ATP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GZMH →	+0.049	+5.285	<.001	.003	3	1
OVARY	GZMK →	+0.034	+5.196	<.001	.005	3	1
BREAST	LCN1 →	+0.050	+4.672	<.001	.002	3	1
BREAST	PAGE3 →	+0.042	+4.781	<.001	.003	3	1
LUNG_SCLC	OR10Q1 →	+0.490	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

MT-ATP8 survival (RNA) · tumor vs normal (RNA) · all MT-ATP8 data types