MSX2

Across TCGA patient cohorts, MSX2 protein abundance is significantly associated with the RNA expression of many other genes, with 5,655 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MSX2-associated genes across cancer lineages are TNN, HSPA2, and SLC18A2. Each is linked with MSX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MSX2-to-partner and partner-to-MSX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MSX2 versus TNN in HNSC, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSX2→partner) and Y-score (partner→MSX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TNN →	+1.650	+0.735	.005	.007	3	3
LSCC	HSPA2 →	+2.292	+0.927	.001	.001	3	3
HNSC	SLC18A2 →	+0.859	+0.855	.002	.001	3	3
BRCA	CST4 →	+1.711	+0.845	.002	<.001	3	2
UCEC	FAM189A1 →	+0.887	+0.525	<.001	.003	3	2
UCEC	CCNE1 →	-1.365	-0.897	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,655 associations by consensus.

MSX2 vs TNN — HNSC

Explore this scatter interactively →