MSX2

Across TCGA patient cohorts, MSX2 mutation is significantly associated with the RNA expression of many other genes, with 665 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSX2-associated genes across cancer lineages are RNU6-1126P, MIR521-1, and RNA5SP113. Each is linked with MSX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSX2-to-partner and partner-to-MSX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1126P grouped by MSX2-low versus MSX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSX2→partner) and Y-score (partner→MSX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1126P →	+0.163	+3.013	<.001	.007	3	2
UCEC	MIR521-1 →	+0.169	+3.260	<.001	.004	3	2
LUSC	RNA5SP113 →	+0.388	+5.438	<.001	.002	3	2
COAD	PRELID3BP7 →	+0.426	+4.266	<.001	.008	3	2
PRAD	RN7SL759P →	+0.114	+7.939	<.001	.008	3	2
UCEC	ZNHIT3 →	+0.476	+3.021	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 665 associations by consensus.

RNU6-1126P by MSX2 expression — UCEC

Explore this box plot interactively →