MSX1

Across TCGA cell cohorts, MSX1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MSX1-associated genes across cancer lineages are LCE2C, NEUROD6, and MYF6. Each is linked with MSX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSX1-to-partner and partner-to-MSX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE2C grouped by MSX1-low versus MSX1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSX1→partner) and Y-score (partner→MSX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LCE2C →	+0.042	+5.662	<.001	.002	3	1
BLOOD_Lymphoma	NEUROD6 →	+0.013	+5.643	<.001	.002	3	1
LARGE_INTESTINE	MYF6 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR1L6 →	+0.027	+5.022	<.001	.002	3	1
LARGE_INTESTINE	NUPR2 →	+0.376	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TBC1D3 →	+0.091	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

LCE2C by MSX1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →