MSTN

Across TCGA patient cohorts, MSTN RNA expression is significantly associated with the protein abundance of many other proteins, with 7,392 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MSTN-associated proteins across cancer lineages are DMXL2_S1857, HNRNPA3, and TNS2_S120. Each is linked with MSTN in more than 2 cancer types. Because this analysis shows association rather than direction, both MSTN-to-partner and partner-to-MSTN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MSTN versus DMXL2_S1857 in BRCA, with a Pearson correlation of -0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MSTN→partner) and Y-score (partner→MSTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DMXL2_S1857 →	-0.645	-0.666	<.001	.002	3	3
LUAD	HNRNPA3 →	+0.193	+0.385	<.001	<.001	3	3
BRCA	TNS2_S120 →	+0.485	+0.426	<.001	.002	3	3
BRCA	HDGFL3 →	+0.807	+0.542	<.001	<.001	3	3
BRCA	EIF4A1 →	-0.196	-0.336	<.001	.006	3	3
COAD	PDPR →	+0.279	+0.210	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,392 associations by consensus.

MSTN vs DMXL2_S1857 — BRCA

Explore this scatter interactively →