MSTN

Across TCGA pan-cancer cohorts, MSTN RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MSTN data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher MSTN RNA is associated with better overall survival. In most high-consensus cancer types, elevated MSTN expression acts as an unfavorable survival marker, although some lineages such as BLCA and HNSC show a favorable association.

BLCA, HNSC, and UVM are the cancer types where MSTN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.688	0.534	<.001	130	view →
HNSC	OS	Tertile	All	0.818	0.715	.005	58	view →
UVM	DFS	Median	III,IV	0.348	0.730	.001	55	view →
MESO	OS	Quartile	III,IV	0.578	0.272	.005	33	view →
READ	OS	Tertile	All	0.814	0.568	.011	28	view →
LIHC	DFS	Median	II,III,IV	0.600	0.286	<.001	26	view →
GBM	OS	Median	All	0.320	0.210	.001	18	view →
COAD	OS	Tertile	II,III,IV	0.827	0.531	.005	17	view →
CHOL	DFS	Quartile	All	0.114	0.456	.006	16	view →
PAAD	OS	Tertile	All	0.653	0.412	.016	16	view →
KIRP	DFS	Tertile	All	0.796	0.911	.013	14	view →
LUAD	OS	Median	All	0.848	0.722	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MSTN–BLCA (OS)

Open the BLCA breakdown →