MSTN

Across TCGA patient cohorts, MSTN mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSTN-associated genes across cancer lineages are 14-3-3_beta, MEK1, and p27_pT157. Each is linked with MSTN in more than 1 cancer types. Because this analysis shows association rather than direction, both MSTN-to-partner and partner-to-MSTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MSTN-low versus MSTN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSTN→partner) and Y-score (partner→MSTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.102	-2.295	.014	.033	3	1
UCEC	MEK1 →	+0.442	+3.459	.003	.005	3	1
UCEC	p27_pT157 →	-0.064	-2.308	.007	.033	3	1
UCEC	p62 Lck ligand →	+0.392	+3.331	.003	.005	3	1
UCEC	PDCD4 →	-0.400	-2.449	.039	.019	3	1
UCEC	PDK1_pS241 →	+0.194	+3.026	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

14-3-3_beta by MSTN expression — UCEC

Explore this box plot interactively →