MSTN

Across TCGA cell cohorts, MSTN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,326 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MSTN-associated GO terms across cancer lineages are [4Fe-4S] cluster assembly, miRNA catabolic process, and Regulation of fever generation. Each is linked with MSTN in more than 7 cancer types. Because this analysis shows association rather than direction, both MSTN-to-partner and partner-to-MSTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, [4Fe-4S] cluster assembly grouped by MSTN-low versus MSTN-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MSTN→partner) and Y-score (partner→MSTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	[4Fe-4S] cluster assembly →	-0.105	-0.097	.001	.007	3	8
OVARY	miRNA catabolic process →	+0.094	+0.118	<.001	.002	3	6
BREAST	Regulation of fever generation →	-1.070	-0.144	<.001	.004	3	6
LARGE_INTESTINE	Excitatory postsynaptic potential →	-0.069	-0.167	<.001	.002	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of macroautophagy →	+0.060	+0.093	<.001	.005	3	6
PANCREAS	ERAD pathway →	+0.080	+0.090	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,326 associations by consensus.

[4Fe-4S] cluster assembly by MSTN expression — PANCREAS

Explore this box plot interactively →