MSS51

Across TCGA patient cohorts, MSS51 mutation is significantly associated with the RNA expression of many other genes, with 1,671 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSS51-associated genes across cancer lineages are PKD1P3, KRTAP23-1, and APOBEC3AP1. Each is linked with MSS51 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSS51-to-partner and partner-to-MSS51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKD1P3 grouped by MSS51-low versus MSS51-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSS51→partner) and Y-score (partner→MSS51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKD1P3 →	+0.353	+3.234	.001	.008	3	2
UCEC	KRTAP23-1 →	+0.189	+2.232	.002	.007	3	2
STAD	APOBEC3AP1 →	+0.255	+3.646	<.001	.009	3	2
UCEC	RN7SL248P →	+0.066	+3.307	<.001	.003	3	2
UCEC	PKN3 →	+0.674	+2.425	<.001	.002	3	2
UCEC	ZMYND19 →	+0.447	+2.447	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,671 associations by consensus.

PKD1P3 by MSS51 expression — UCEC

Explore this box plot interactively →