Across TCGA patient cohorts, MSRB1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSRB1-associated genes across cancer lineages are RN7SKP172, NRXN2-AS1, and RPS17P11. Each is linked with MSRB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSRB1-to-partner and partner-to-MSRB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSRB1→partner) and Y-score (partner→MSRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP172 →	+0.226	+4.136	<.001	.001	3	1
UCEC	NRXN2-AS1 →	+0.504	+3.604	<.001	.009	3	1
UCEC	RPS17P11 →	+0.091	+4.132	.009	.009	3	1
UCEC	CYCTP →	+0.293	+3.204	.005	.006	3	1
UCEC	LINC02108 →	+0.099	+4.135	.007	<.001	3	1
UCEC	LINC02685 →	+0.128	+3.303	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

MSRB1 survival (RNA) · tumor vs normal (RNA) · all MSRB1 data types