MSRA

Across TCGA patient cohorts, MSRA mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSRA-associated genes across cancer lineages are JNK2, STAT3_pY705, and Tuberin. Each is linked with MSRA in more than 1 cancer types. Because this analysis shows association rather than direction, both MSRA-to-partner and partner-to-MSRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by MSRA-low versus MSRA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSRA→partner) and Y-score (partner→MSRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.275	+3.321	.008	.010	3	1
UCEC	STAT3_pY705 →	-0.469	-3.169	<.001	.018	3	1
UCEC	Tuberin →	+0.392	+2.817	.005	.036	3	1
UCEC	Bak →	+0.300	+3.321	.022	.010	2	2
UCEC	Caspase-8 →	-0.337	-2.973	.010	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.229	-3.000	.009	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

JNK2 by MSRA expression — UCEC

Explore this box plot interactively →