MSRA

Across TCGA pan-cancer cohorts, MSRA RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of MSRA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MSRA RNA is repressed in tumor relative to normal tissue. In most cancer types MSRA is over-expressed in tumor, although a few such as KIRP and HNSC show the opposite, repressed pattern.

KIRP, HNSC, and COAD are the cancer types where MSRA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MSRA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−1.885	<.001	11	view →
HNSC	All	III,IV	−0.588	<.001	11	view →
COAD	Female	All	−0.832	<.001	10	view →
BLCA	All	All	−0.628	<.001	9	view →
KICH	Female	II,III,IV	−2.378	<.001	8	view →
LUSC	Male	III,IV	−1.679	<.001	8	view →
LUAD	Male	All	−0.721	<.001	8	view →
LIHC	Female	II,III,IV	−1.126	<.001	7	view →
BRCA	All	II,III,IV	−1.104	<.001	6	view →
THCA	All	All	+0.188	.001	4	view →
CHOL	All	All	−1.176	<.001	3	view →
READ	Female	All	−0.976	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

MSRA–KIRP

Open the KIRP breakdown →