MSRA

Across TCGA cell cohorts, MSRA mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MSRA-associated genes across cancer lineages are CCER1 and BPIFA1. Each is linked with MSRA in more than 1 cancer types. Because this analysis shows association rather than direction, both MSRA-to-partner and partner-to-MSRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCER1 grouped by MSRA-low versus MSRA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSRA→partner) and Y-score (partner→MSRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCER1 →	+0.008	+3.240	<.001	.004	3	1
LARGE_INTESTINE	BPIFA1 →	+0.159	+2.688	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CCER1 by MSRA expression — LARGE_INTESTINE

Explore this box plot interactively →