MSR1

Across TCGA pan-cancer cohorts, MSR1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated MSR1 data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MSR1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MSR1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where MSR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	III,IV	0.792	1.000	.018	48	view →
PDAC	DFS	Quartile	All	0.295	0.638	.002	34	view →
HNSC	OS	Median	IV	0.867	0.594	.003	27	view →
GBM	OS	Tertile	All	0.372	0.718	.002	13	view →
UCEC	DFS	Tertile	All	0.854	1.000	.006	10	view →
CCRCC	DFS	Quartile	III,IV	0.497	0.882	.012	8	view →
LSCC	OS	Quartile	All	0.810	0.987	.033	3	view →
LUAD	OS	Quartile	II,III,IV	0.284	0.798	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

MSR1–COAD (DFS)

Open the COAD breakdown →