MSR1

Across TCGA pan-cancer cohorts, MSR1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MSR1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MSR1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MSR1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where MSR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MSR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+2.304	<.001	12	view →
HNSC	All	III,IV	+1.268	<.001	12	view →
KIRP	Male	All	+1.616	<.001	11	view →
THCA	Male	II,III,IV	+1.207	<.001	10	view →
LUAD	Female	III,IV	−2.559	<.001	9	view →
LUSC	Female	II,III,IV	−3.431	<.001	8	view →
STAD	All	II,III,IV	+1.707	<.001	8	view →
BRCA	All	III,IV	+1.262	<.001	6	view →
COAD	All	II,III,IV	+0.622	.007	5	view →
ESCA	Male	All	+1.692	.037	2	view →
BLCA	Female	III,IV	+1.134	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MSR1–KIRC

Open the KIRC breakdown →