MSR1

Across TCGA patient cohorts, MSR1 mutation is significantly associated with the RNA expression of many other genes, with 4,327 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSR1-associated genes across cancer lineages are EXOSC7, EXOSC3, and LSM3. Each is linked with MSR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MSR1-to-partner and partner-to-MSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXOSC7 grouped by MSR1-low versus MSR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSR1→partner) and Y-score (partner→MSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EXOSC7 →	+0.351	+2.233	<.001	<.001	3	4
UCEC	EXOSC3 →	+0.456	+1.947	<.001	<.001	3	4
UCEC	LSM3 →	+0.528	+2.536	<.001	<.001	3	4
UCEC	IDI1 →	+0.467	+2.119	.003	.003	3	4
SKCM	MYL12A →	+0.301	+1.101	<.001	.005	3	3
UCEC	DHODH →	+0.377	+3.064	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,327 associations by consensus.

EXOSC7 by MSR1 expression — UCEC

Explore this box plot interactively →