MSR1

Across TCGA patient cohorts, MSR1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSR1-associated genes across cancer lineages are FoxM1, ACVRL1, and Claudin-7. Each is linked with MSR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MSR1-to-partner and partner-to-MSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by MSR1-low versus MSR1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSR1→partner) and Y-score (partner→MSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FoxM1 →	+0.341	+3.169	.008	.019	3	4
STAD	ACVRL1 →	-0.227	-3.000	.033	.034	3	3
LUSC	Claudin-7 →	+0.703	+3.009	.005	.019	3	2
STAD	Collagen-VI →	-0.457	-3.169	<.001	.018	3	2
UCEC	MEK1 →	+0.339	+2.700	.004	.005	3	2
UCEC	Cyclin-B1 →	+0.814	+3.754	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

FoxM1 by MSR1 expression — STAD

Explore this box plot interactively →