MSR1

Across TCGA cell cohorts, MSR1 mutation is significantly associated with the RNA expression of many other genes, with 169 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MSR1-associated genes across cancer lineages are OR1D5, PROP1, and SRARP. Each is linked with MSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSR1-to-partner and partner-to-MSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1D5 grouped by MSR1-low versus MSR1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSR1→partner) and Y-score (partner→MSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR1D5 →	+0.046	+5.781	<.001	.001	3	2
BLOOD_Leukemia	PROP1 →	+0.027	+3.874	<.001	.005	3	2
BLOOD_Leukemia	SRARP →	+0.007	+4.691	<.001	<.001	3	2
PANCREAS	FSHB →	+0.046	+5.614	<.001	.002	3	1
PANCREAS	TP53TG3E →	+0.012	+5.000	<.001	.006	3	1
BREAST	LAIR2 →	+0.098	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 169 associations by consensus.

OR1D5 by MSR1 expression — BREAST

Explore this box plot interactively →