MSN

Across TCGA pan-cancer cohorts, MSN mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MSN data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MSN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MSN expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

COAD, GBM, and LUAD are the cancer types where MSN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.888	1.000	.023	30	view →
GBM	OS	Quartile	All	0.305	0.686	.001	21	view →
LUAD	OS	Tertile	III,IV	0.387	0.920	.036	7	view →
LSCC	DFS	Quartile	II,III,IV	0.507	0.939	.007	6	view →
PDAC	DFS	Median	All	0.215	0.432	.006	6	view →
HNSC	OS	Tertile	All	0.944	0.816	.046	1	view →
CCRCC	DFS	Quartile	II,III,IV	0.933	0.707	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MSN–COAD (DFS)

Open the COAD breakdown →