MSN

Across TCGA patient cohorts, MSN mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSN-associated genes across cancer lineages are PDCD4, RAD51, and EGFR. Each is linked with MSN in more than 2 cancer types. Because this analysis shows association rather than direction, both MSN-to-partner and partner-to-MSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by MSN-low versus MSN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSN→partner) and Y-score (partner→MSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.411	-1.263	.004	.019	3	3
STAD	RAD51 →	+0.272	+3.169	.013	.019	3	2
UCEC	EGFR →	-0.124	-1.502	.011	.027	3	2
UCEC	HER2_pY1248 →	-0.167	-1.700	.041	.001	3	2
UCEC	PCNA →	+0.201	+1.700	.002	.001	3	2
UCEC	Rab25 →	-0.336	-2.321	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PDCD4 by MSN expression — UCEC

Explore this box plot interactively →