MSN

Across TCGA cell cohorts, MSN RNA expression is significantly associated with the go_rna of many other GO terms, with 5,750 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MSN-associated GO terms across cancer lineages are Establishment of epithelial cell apical/basal polarity, Establishment of apical/basal cell polarity, and Establishment of monopolar cell polarity. Each is linked with MSN in more than 17 cancer types. Because this analysis shows association rather than direction, both MSN-to-partner and partner-to-MSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of epithelial cell apical/basal polarity grouped by MSN-low versus MSN-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MSN→partner) and Y-score (partner→MSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Establishment of epithelial cell apical/basal polarity →	+0.266	+3.808	<.001	.005	3	18
URINARY_TRACT	Establishment of apical/basal cell polarity →	+0.180	+4.149	<.001	<.001	3	15
PANCREAS	Establishment of monopolar cell polarity →	+0.182	+3.678	<.001	<.001	3	15
PANCREAS	Immunological synapse formation →	+0.469	+2.691	.001	<.001	3	14
LIVER	Leukocyte aggregation →	+0.607	+3.032	.002	.001	3	14
KIDNEY	Response to oscillatory fluid shear stress →	+0.161	+0.994	.001	.004	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,750 associations by consensus.

Establishment of epithelial cell apical/basal polarity by MSN expression — LIVER

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