MSN

Across TCGA cell cohorts, MSN mutation is significantly associated with the RNA expression of many other genes, with 153 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MSN-associated genes across cancer lineages are OR2L8, GCAT, and PITX3. Each is linked with MSN in more than 1 cancer types. Because this analysis shows association rather than direction, both MSN-to-partner and partner-to-MSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by MSN-low versus MSN-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSN→partner) and Y-score (partner→MSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2L8 →	+0.041	+4.450	<.001	.004	3	2
LARGE_INTESTINE	GCAT →	+1.480	+3.502	<.001	.001	3	1
LARGE_INTESTINE	PITX3 →	+0.121	+2.152	<.001	.009	3	1
LARGE_INTESTINE	MTMR4 →	+0.661	+3.502	.004	.001	3	1
LARGE_INTESTINE	NDUFC1 →	+0.573	+3.502	.006	.001	3	1
LARGE_INTESTINE	KLHL2 →	+0.655	+3.169	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 153 associations by consensus.

OR2L8 by MSN expression — OVARY

Explore this box plot interactively →