MSI2

Across TCGA patient cohorts, MSI2 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,715 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible MSI2-associated proteins across cancer lineages are LIG3, SNRNP40, and ADNP. Each is linked with MSI2 in more than 5 cancer types. Because this analysis shows association rather than direction, both MSI2-to-partner and partner-to-MSI2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MSI2 versus LIG3 in LSCC, with a Pearson correlation of 0.58.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MSI2→partner) and Y-score (partner→MSI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LIG3 →	+0.436	+0.663	<.001	<.001	3	6
GBM	SNRNP40 →	+0.204	+0.535	.003	.001	3	5
LSCC	ADNP →	+0.358	+0.744	.001	<.001	3	5
GBM	UBTF →	+0.249	+0.499	.005	.001	3	5
HNSC	UPP1 →	-0.787	-0.667	<.001	<.001	3	5
LUAD	UPP1_S61 →	-0.591	-0.408	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,715 associations by consensus.

MSI2 vs LIG3 — LSCC

Explore this scatter interactively →