MSI1

Across TCGA patient cohorts, MSI1 mutation is significantly associated with the RNA expression of many other genes, with 319 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSI1-associated genes across cancer lineages are LINC01848, RNU1-75P, and RN7SL250P. Each is linked with MSI1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MSI1-to-partner and partner-to-MSI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01848 grouped by MSI1-low versus MSI1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSI1→partner) and Y-score (partner→MSI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC01848 →	+0.229	+3.408	<.001	.009	3	3
STAD	RNU1-75P →	+0.568	+4.254	<.001	.008	3	3
CESC	RN7SL250P →	+0.513	+3.653	.006	.009	3	2
SKCM	HPYR1 →	+0.047	+3.408	.001	.009	3	2
COAD	RNA5SP378 →	+1.014	+4.081	<.001	.004	3	2
CESC	ERHP2 →	+0.174	+3.996	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 319 associations by consensus.

LINC01848 by MSI1 expression — SKCM

Explore this box plot interactively →