MSH6

Across TCGA cell cohorts, MSH6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,717 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MSH6-associated GO terms across cancer lineages are Regulation of chromosome condensation, DNA-templated DNA replication, and Double-strand break repair. Each is linked with MSH6 in more than 18 cancer types. Because this analysis shows association rather than direction, both MSH6-to-partner and partner-to-MSH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome condensation grouped by MSH6-low versus MSH6-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH6→partner) and Y-score (partner→MSH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of chromosome condensation →	+0.193	+2.123	<.001	<.001	3	19
BONE	DNA-templated DNA replication →	+0.132	+0.984	.001	<.001	3	19
OESOPHAGUS	Double-strand break repair →	+0.086	+0.930	<.001	.001	3	19
OESOPHAGUS	Recombinational repair →	+0.098	+0.832	.003	<.001	3	19
OESOPHAGUS	DNA strand elongation →	+0.179	+0.889	<.001	<.001	3	19
OESOPHAGUS	Double-strand break repair via homologous recombination →	+0.096	+0.933	.002	.002	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,717 associations by consensus.

Regulation of chromosome condensation by MSH6 expression — BLOOD_Lymphoma

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