MSH6

Across TCGA pan-cancer cohorts, MSH6 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MSH6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MSH6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MSH6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where MSH6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MSH6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.457	<.001	11	view →
COAD	Male	III,IV	+0.796	<.001	10	view →
LIHC	Female	II,III,IV	+1.140	<.001	9	view →
BLCA	Female	All	+1.004	<.001	9	view →
LUAD	Male	All	+0.926	<.001	9	view →
BRCA	All	III,IV	+0.651	<.001	8	view →
THCA	Female	All	−0.396	<.001	8	view →
LUSC	Female	All	+1.636	<.001	7	view →
STAD	All	II,III,IV	+0.827	<.001	6	view →
KIRC	Male	All	+0.369	<.001	6	view →
CHOL	All	All	+1.673	<.001	5	view →
KICH	Female	All	−1.339	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MSH6–HNSC

Open the HNSC breakdown →