MSH6

Across TCGA cell cohorts, MSH6 mutation is significantly associated with the RNA expression of many other genes, with 1,398 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MSH6-associated genes across cancer lineages are FAM229B, POMGNT2, and FBXW10. Each is linked with MSH6 in more than 2 cancer types. Because this analysis shows association rather than direction, both MSH6-to-partner and partner-to-MSH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM229B grouped by MSH6-low versus MSH6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH6→partner) and Y-score (partner→MSH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM229B →	+0.996	+3.199	.002	.007	3	3
BLOOD_Leukemia	POMGNT2 →	+1.107	+3.199	.009	.007	3	2
LARGE_INTESTINE	FBXW10 →	+0.161	+2.714	.001	.001	3	2
LARGE_INTESTINE	FUT10 →	+0.807	+4.212	<.001	<.001	3	2
BLOOD_Leukemia	CLN8 →	+0.864	+3.199	<.001	.007	3	2
BLOOD_Leukemia	RNF19A →	+0.645	+3.378	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,398 associations by consensus.

FAM229B by MSH6 expression — BLOOD_Leukemia

Explore this box plot interactively →