Across TCGA patient cohorts, MSH5 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,853 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MSH5-associated proteins across cancer lineages are ACTL6A_S233, CPSF3, and DHX9. Each is linked with MSH5 in more than 5 cancer types. Because this analysis shows association rather than direction, both MSH5-to-partner and partner-to-MSH5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH5→partner) and Y-score (partner→MSH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ACTL6A_S233 →	+0.903	+0.469	<.001	<.001	3	6
LSCC	CPSF3 →	+0.227	+0.344	<.001	<.001	3	6
GBM	DHX9 →	+0.214	+0.508	<.001	<.001	3	6
GBM	LIG3 →	+0.382	+0.391	<.001	<.001	3	6
UCEC	RNF5 →	+0.571	+1.048	<.001	<.001	3	5
LSCC	SRSF9_S204 →	+0.532	+0.334	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,853 associations by consensus.

Exploration

MSH5 survival (RNA) · tumor vs normal (RNA) · all MSH5 data types