Across TCGA pan-cancer cohorts, MSH5 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated MSH5 data layer compared with 5 for mutation status.
The strongest signal is observed in kidney chromophobe (KICH), where higher MSH5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MSH5 expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.
KICH, KIRC, and ACC are the cancer types where MSH5 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.