Across TCGA patient cohorts, MSH5 mutation is significantly associated with the RNA expression of many other genes, with 4,574 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSH5-associated genes across cancer lineages are WDR62, RN7SL237P, and UBE2L3. Each is linked with MSH5 in more than 2 cancer types. Because this analysis shows association rather than direction, both MSH5-to-partner and partner-to-MSH5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH5→partner) and Y-score (partner→MSH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR62 →	+0.749	+2.513	<.001	<.001	3	3
CESC	RN7SL237P →	+0.112	+3.681	<.001	.003	3	3
UCEC	UBE2L3 →	+0.378	+2.258	<.001	<.001	3	3
UCEC	LONP1 →	+0.735	+3.180	<.001	<.001	3	3
BRCA	MIR6821 →	+0.626	+3.658	<.001	.004	3	2
UCEC	DHX37 →	+0.363	+2.375	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,574 associations by consensus.

Exploration

MSH5 survival (RNA) · tumor vs normal (RNA) · all MSH5 data types