Across TCGA cell cohorts, MSH5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,201 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MSH5-associated GO terms across cancer lineages are Chiasma assembly, De novo centriole assembly, and De novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Each is linked with MSH5 in more than 19 cancer types. Because this analysis shows association rather than direction, both MSH5-to-partner and partner-to-MSH5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH5→partner) and Y-score (partner→MSH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Chiasma assembly →	+0.424	+1.667	<.001	<.001	3	20
PANCREAS	De novo centriole assembly →	+0.140	+0.967	<.001	.003	3	17
PANCREAS	De novo centriole assembly involved in multi-ciliated epithelial cell differentiation →	+0.132	+0.978	.001	.002	3	17
LARGE_INTESTINE	Telomere organization →	+0.072	+1.767	<.001	<.001	3	16
BONE	Mitotic DNA damage checkpoint signaling →	+0.108	+1.449	<.001	.001	3	16
BONE	Microtubule organizing center organization →	+0.089	+1.743	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,201 associations by consensus.

Exploration

MSH5 survival (RNA) · tumor vs normal (RNA) · all MSH5 data types