Across TCGA cell cohorts, MSH5 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MSH5-associated genes across cancer lineages are USP17L22, SIRPD, and DEFB125. Each is linked with MSH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSH5-to-partner and partner-to-MSH5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH5→partner) and Y-score (partner→MSH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	USP17L22 →	+0.027	+4.392	<.001	.003	3	2
LUNG_SCLC	SIRPD →	+0.058	+5.029	<.001	.006	3	1
LUNG_SCLC	DEFB125 →	+0.086	+5.643	<.001	.002	3	1
LARGE_INTESTINE	MMP26 →	+0.039	+3.632	<.001	.003	3	1
BLOOD_Leukemia	TCF21 →	+0.008	+3.705	.002	.007	3	1
BLOOD_Leukemia	ADRA1A →	+0.165	+3.705	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

MSH5 survival (RNA) · tumor vs normal (RNA) · all MSH5 data types