MSH5-SAPCD1

Across TCGA pan-cancer cohorts, MSH5-SAPCD1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated MSH5-SAPCD1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MSH5-SAPCD1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MSH5-SAPCD1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and READ show a favorable association.

KIRC, ACC, and HNSC are the cancer types where MSH5-SAPCD1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.554	0.736	<.001	108	view →
ACC	OS	Tertile	All	0.603	0.925	<.001	68	view →
HNSC	OS	Tertile	II,III,IV	0.503	0.292	.002	66	view →
LGG	DFS	Median	All	0.655	0.805	<.001	48	view →
READ	OS	Median	II,III,IV	0.986	0.834	.002	47	view →
LIHC	DFS	Tertile	All	0.451	0.625	.001	43	view →
BLCA	DFS	Median	III,IV	0.539	0.393	.002	43	view →
PAAD	OS	Tertile	All	0.501	0.236	.005	32	view →
COAD	DFS	Tertile	All	0.431	0.703	.005	26	view →
SKCM	DFS	Tertile	III,IV	0.637	0.393	.007	20	view →
PRAD	DFS	Median	All	0.699	0.867	<.001	20	view →
BRCA	OS	Median	All	0.666	0.511	.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

MSH5-SAPCD1–KIRC (OS)

Open the KIRC breakdown →