MSH5-SAPCD1

Across TCGA pan-cancer cohorts, MSH5-SAPCD1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MSH5-SAPCD1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MSH5-SAPCD1 RNA is repressed in tumor relative to normal tissue. In most cancer types MSH5-SAPCD1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, LIHC, and KIRC are the cancer types where MSH5-SAPCD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MSH5-SAPCD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−0.529	<.001	11	view →
LIHC	All	III,IV	+0.397	<.001	9	view →
KIRC	All	III,IV	−0.181	<.001	9	view →
BLCA	All	All	+0.248	<.001	8	view →
STAD	All	All	+0.326	<.001	6	view →
THCA	Female	All	+0.256	<.001	5	view →
COAD	Male	II,III,IV	+0.244	.006	4	view →
BRCA	Female	All	−0.091	.002	4	view →
CHOL	All	All	+1.022	<.001	3	view →
ESCA	All	II,III,IV	+0.740	.010	3	view →
UCEC	All	III,IV	−0.325	.013	2	view →
PRAD	All	All	+0.094	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MSH5-SAPCD1–KICH

Open the KICH breakdown →