MSH4

Across TCGA cell cohorts, MSH4 mutation is significantly associated with the RNA expression of many other genes, with 243 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MSH4-associated genes across cancer lineages are PZP, KCNG4, and CRX. Each is linked with MSH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSH4-to-partner and partner-to-MSH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PZP grouped by MSH4-low versus MSH4-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH4→partner) and Y-score (partner→MSH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PZP →	+0.036	+4.807	<.001	.006	3	1
OESOPHAGUS	KCNG4 →	+0.007	+4.857	<.001	<.001	3	1
LUNG_NSCLC_LUSC	CRX →	+0.057	+3.514	.001	.008	3	1
LUNG_NSCLC_LUAD	PTH2 →	+0.151	+3.481	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR7G3 →	+0.021	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	CCL19 →	+0.090	+3.887	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 243 associations by consensus.

PZP by MSH4 expression — BLOOD_Myeloma

Explore this box plot interactively →