MSH3

Across TCGA pan-cancer cohorts, MSH3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MSH3 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MSH3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MSH3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and CCRCC are the cancer types where MSH3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	1.000	0.449	.010	30	view →
HNSC	OS	Median	III,IV	0.815	0.550	.001	16	view →
CCRCC	OS	Median	III,IV	0.133	0.989	.013	3	view →
GBM	DFS	Median	All	0.415	0.233	.030	2	view →
PDAC	OS	Quartile	II,III,IV	0.707	0.923	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MSH3–UCEC (OS)

Open the UCEC breakdown →