MSH3

Across TCGA patient cohorts, MSH3 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSH3-associated genes across cancer lineages are Annexin-1, ASNS, and GAPDH. Each is linked with MSH3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MSH3-to-partner and partner-to-MSH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by MSH3-low versus MSH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH3→partner) and Y-score (partner→MSH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.564	+2.720	.001	.003	3	3
UCEC	ASNS →	+0.379	+2.000	.002	.029	3	3
UCEC	GAPDH →	+0.440	+2.000	.018	.029	3	2
UCEC	INPP4B →	-0.239	-2.321	.033	.005	3	2
UCEC	p27_pT198 →	+0.089	+2.222	.016	.010	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.547	-2.087	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Annexin-1 by MSH3 expression — UCEC

Explore this box plot interactively →