MSH3

Across TCGA cell cohorts, MSH3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,204 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MSH3-associated GO terms across cancer lineages are Double-strand break repair via nonhomologous end joining, Mitotic recombination, and Dihydrofolate metabolic process. Each is linked with MSH3 in more than 14 cancer types. Because this analysis shows association rather than direction, both MSH3-to-partner and partner-to-MSH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via nonhomologous end joining grouped by MSH3-low versus MSH3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH3→partner) and Y-score (partner→MSH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via nonhomologous end joining →	+0.073	+0.783	<.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Mitotic recombination →	+0.100	+0.757	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Dihydrofolate metabolic process →	+0.206	+0.675	.001	.001	3	13
BLOOD_Lymphoma	Immunoglobulin production →	+0.066	+0.772	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Protein autoubiquitination →	+0.083	+0.871	<.001	<.001	3	13
OVARY	Regulation of microtubule-based process →	+0.051	+0.698	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,204 associations by consensus.

Double-strand break repair via nonhomologous end joining by MSH3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →