MSH3

Across TCGA cell cohorts, MSH3 mutation is significantly associated with the RNA expression of many other genes, with 1,331 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MSH3-associated genes across cancer lineages are S100G, GCH1, and IRF2. Each is linked with MSH3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MSH3-to-partner and partner-to-MSH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S100G grouped by MSH3-low versus MSH3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH3→partner) and Y-score (partner→MSH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	S100G →	+0.399	+3.095	<.001	.009	3	2
BLOOD_Leukemia	GCH1 →	+1.294	+3.199	.007	.007	2	3
BLOOD_Leukemia	IRF2 →	+0.799	+3.199	.003	.007	3	2
LARGE_INTESTINE	PRPS2 →	+0.531	+2.743	.004	.001	3	2
LARGE_INTESTINE	NT5DC3 →	+0.935	+2.743	<.001	.001	3	2
LARGE_INTESTINE	MYB →	+1.471	+2.043	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,331 associations by consensus.

S100G by MSH3 expression — OVARY

Explore this box plot interactively →