MSC

Across TCGA patient cohorts, MSC mutation is significantly associated with the RNA expression of many other genes, with 2,913 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSC-associated genes across cancer lineages are DYNLL1P6, BUB3, and AIMP1. Each is linked with MSC in more than 3 cancer types. Because this analysis shows association rather than direction, both MSC-to-partner and partner-to-MSC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DYNLL1P6 grouped by MSC-low versus MSC-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSC→partner) and Y-score (partner→MSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	DYNLL1P6 →	+0.193	+4.672	<.001	.004	3	3
COAD	BUB3 →	+0.488	+2.834	<.001	.001	3	3
UCEC	AIMP1 →	+0.608	+3.639	<.001	.001	3	3
UCEC	HSPA4L →	+1.063	+2.436	<.001	.002	3	3
UCEC	SFXN1 →	+0.519	+3.880	<.001	<.001	2	4
UCEC	TRIAP1 →	+0.518	+3.732	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,913 associations by consensus.

DYNLL1P6 by MSC expression — READ

Explore this box plot interactively →