MSC

Across TCGA pan-cancer cohorts, MSC RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MSC data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MSC RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MSC expression acts as an unfavorable survival marker, although some lineages such as UVM and UCEC show a favorable association.

KIRC, UVM, and MESO are the cancer types where MSC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.748	0.860	<.001	108	view →
UVM	OS	Median	All	0.827	0.408	<.001	105	view →
MESO	OS	Median	All	0.272	0.503	<.001	60	view →
UCEC	OS	Quartile	II,III,IV	0.890	0.784	.014	48	view →
SKCM	OS	Tertile	III,IV	0.285	0.578	<.001	45	view →
LIHC	OS	Quartile	II,III,IV	0.391	0.705	<.001	39	view →
ACC	DFS	Quartile	All	1.000	0.300	<.001	35	view →
HNSC	DFS	Tertile	All	0.581	0.813	.001	30	view →
KIRP	DFS	Tertile	All	0.543	0.824	.001	22	view →
LUAD	DFS	Quartile	II,III,IV	0.626	0.349	.009	19	view →
UCS	DFS	Quartile	II,III,IV	0.603	0.147	.011	18	view →
SCLC	DFS	Quartile	All	0.579	0.272	.010	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MSC–KIRC (OS)

Open the KIRC breakdown →