MSC

Across TCGA patient cohorts, MSC mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSC-associated genes across cancer lineages are ATM, GAPDH, and 4E-BP1. Each is linked with MSC in more than 2 cancer types. Because this analysis shows association rather than direction, both MSC-to-partner and partner-to-MSC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MSC-low versus MSC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSC→partner) and Y-score (partner→MSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.612	-3.169	.002	.019	3	3
STAD	GAPDH →	+0.426	+3.321	.008	.010	3	2
STAD	4E-BP1 →	+0.341	+3.321	.015	.010	3	2
STAD	Cyclin-E2 →	+0.129	+2.190	.042	.033	3	2
LUAD	p70-S6K →	+0.385	+3.169	<.001	.019	3	2
COAD	EGFR_pY1068 →	-0.367	-3.000	.009	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ATM by MSC expression — UCEC

Explore this box plot interactively →