MSC

Across TCGA cell cohorts, MSC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,484 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MSC-associated GO terms across cancer lineages are Collagen biosynthetic process, Response to carbon dioxide, and Collagen metabolic process. Each is linked with MSC in more than 8 cancer types. Because this analysis shows association rather than direction, both MSC-to-partner and partner-to-MSC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Collagen biosynthetic process grouped by MSC-low versus MSC-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MSC→partner) and Y-score (partner→MSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Collagen biosynthetic process →	+0.158	+1.781	<.001	.001	3	9
KIDNEY	Response to carbon dioxide →	+0.865	+3.170	.005	<.001	3	9
CNS	Collagen metabolic process →	+0.219	+2.174	<.001	<.001	3	8
OVARY	Positive regulation of supramolecular fiber organization →	+0.090	+1.702	<.001	.003	3	8
LUNG_NSCLC_LUAD	Establishment of epithelial cell apical/basal polarity →	+0.175	+1.959	<.001	.001	3	8
SOFT_TISSUE	Detection of light stimulus →	-0.066	-2.037	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,484 associations by consensus.

Collagen biosynthetic process by MSC expression — OVARY

Explore this box plot interactively →