MSC

Across TCGA cell cohorts, MSC mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MSC-associated genes across cancer lineages are BPIFA1, ARGFX, and OR2W1. Each is linked with MSC in more than 1 cancer types. Because this analysis shows association rather than direction, both MSC-to-partner and partner-to-MSC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFA1 grouped by MSC-low versus MSC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSC→partner) and Y-score (partner→MSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPIFA1 →	+0.098	+2.688	.008	.008	3	1
LUNG_NSCLC_LUAD	ARGFX →	+0.014	+4.662	.002	.005	3	1
LUNG_NSCLC_LUAD	OR2W1 →	+0.021	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRAMEF11 →	+0.004	+4.662	<.001	.005	3	1
LARGE_INTESTINE	F13B →	+0.054	+3.464	.005	.004	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

BPIFA1 by MSC expression — LARGE_INTESTINE

Explore this box plot interactively →